Sierra platinum: a fast and robust peak-caller for replicated ChIP-seq experiments with visual quality-control and -steering

TitleSierra platinum: a fast and robust peak-caller for replicated ChIP-seq experiments with visual quality-control and -steering
Publication TypeJournal Article
Year of Publication2016
AuthorsMüller, Lydia, Gerighausen Daniel, Farman Mariam, and Zeckzer Dirk
JournalBMC Bioinformatics
Volume17
Issue1
Start Page1
Pagination1--13
Date Published09/2016
ISSN1471-2105
AbstractHistone modifications play an important role in gene regulation. Their genomic locations are of great interest. Usually, the location is measured by ChIP-seq and analyzed with a peak-caller. Replicated ChIP-seq experiments become more and more available. However, their analysis is based on single-experiment peak-calling or on tools like PePr which allows peak-calling of replicates but whose underlying model might not be suitable for the conditions under which the experiments are performed.
URLhttp://dx.doi.org/10.1186/s12859-016-1248-6
DOI10.1186/s12859-016-1248-6
Refereed DesignationRefereed
Undefined