@article {695, title = {Sierra platinum: a fast and robust peak-caller for replicated ChIP-seq experiments with visual quality-control and -steering}, journal = {BMC Bioinformatics}, volume = {17}, year = {2016}, month = {09/2016}, pages = {1--13}, chapter = {1}, abstract = {Histone modifications play an important role in gene regulation. Their genomic locations are of great interest. Usually, the location is measured by ChIP-seq and analyzed with a peak-caller. Replicated ChIP-seq experiments become more and more available. However, their analysis is based on single-experiment peak-calling or on tools like PePr which allows peak-calling of replicates but whose underlying model might not be suitable for the conditions under which the experiments are performed.}, issn = {1471-2105}, doi = {10.1186/s12859-016-1248-6}, url = {http://dx.doi.org/10.1186/s12859-016-1248-6}, author = {Lydia M{\"u}ller and Daniel Wiegreffe and Mariam Farman and Dirk Zeckzer} }